For the first time since 2001, the Los Angeles Rams (3-2) and San Francisco 49ers (4-0) will square off with both teams above .500. The Rams will host the NFC West-leading 49ers in what's a crucial early-season matchup for Sean McVay's team. We focus on the Rams vs. 49ers odds and lines, with sports betting tips and picks around the matchup.
The game will kick off at 4:05 p.m. ET on Sunday.
49ers at Rams: Week 6 preview, betting trends and notes
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- The Rams are 4-1 ATS this season, while the 49ers are 3-1.
- The Rams are 10-3 SU against the NFC West since Sean McVay took over as head coach in 2017. The 49ers are 2-10 against divisional opponents since 2017.
- The 49ers are 1-5 ATS in their last six games against the NFC West.
- Rams are 7-1 ATS in their last eight against NFC opponents.
- The total has gone over in five of the last six games between the Rams and 49ers at the Coliseum.
- The over is 6-0 in the 49ers' last six games in Week 6. It is also 4-1 in the Rams' last five Week 6 games.
- The Rams have allowed 85 total points in the last two weeks, both losses.
49ers at Rams: Key injuries
The 49ers will be without LT Joe Staley, as well as FB Kyle Juszczyk and RT Mike McGlinchey.
Rams RB Todd Gurley and CB Aqib Talib are uncertain as they deal with injuries of their own. WR Brandin Cooks should be available for Los Angeles.
49ers at Rams: Odds, betting lines and prediction
Odds via BetMGM; access USA TODAY Sports' betting odds for a full list. Lines last updated Thursday at 2:30 p.m. ET.
Rams 28, 49ers 24
Moneyline ( ?)
The Rams are dealing with injuries of their own and Todd Gurley missing this one would be a huge blow. However, the sure absences of Staley, Juszczyk and McGlinchey significantly hurt the 49ers offense and could leave Jimmy Garoppolo under constant duress. Take the Rams moneyline (-182) with them trying to bounce back from consecutive losses.
New to sports betting? A $10 wager on the Rams' ML would return a profit of $5.49 with a LA Rams victory.
Against the Spread ( ?)
The spread sits at 3.5 points in favor of the Rams, which is more than you'd probably expect for a 3-2 team facing a 4-0 squad. But Los Angeles has played better than its record indicates and is still a Super Bowl contender. Give the points and take the Rams in this one at -3.5 (100), especially with the game being at home.
Over/Under ( ?)
Though the Rams and 49ers offenses operate differently, they're both effective in their own ways. Los Angeles is explosive and relies on throwing the ball frequently, while San Francisco is more methodical, leaning on the running game. The Rams defense has been shaky and could easily give up 30 points to San Francisco, too. The over/under is high at 50.5 points, but take the OVER (-110). They've combined for at least 47 points in each of their last four meetings.
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