THE plight of terminally-ill Charlie Gard drew international sympathy and saw interventions from the Pope and US president Donald Trump.
After a five-month legal battle, Charlie’s parents, Chris Gard and Connie Yates, ended their legal fight over treatment for their baby son and it was ordered he should be moved to a hospice.
Today a family spokeswoman confirmed the tot had died as his devastated mum paid tribute to her brave little boy.
In a statement issued on Friday mum Connie Yates said: "Our beautiful little boy has gone, we are so proud of you Charlie."
After a harrowing legal battle that prompted a global debate over who has the moral right to decide the fate of a sick child, a judge on Thursday ordered that Charlie be moved to a hospice where the ventilator that keeps him alive would be turned off.
Mum Connie and the baby's father Chris Gard had wanted Charlie to undergo a treatment that has never been tried on anyone with his condition before, against the advice of doctors at his London hospital who said it would not benefit him and would prolong his suffering.
The case drew comment from U.S. President Donald Trump, who tweeted on July 3 that "we would be delighted" to help Charlie, and from Pope Francis, who called for the parents to be allowed to do everything possible to treat their child.
Britain's courts, after hearing a wealth of medical evidence, ruled that it would go against Charlie's best interests to have the experimental nucleoside therapy advocated by a U.S. professor of neurology, Michio Hirano.
WORLD WATCHED FIGHT FOR CHARLIE
January 2017 - A crowd-funding page is set up to help finance trial therapy in the United States.
March 3 2017 - Great Ormond Street bosses ask Mr Justice Francis to rule that life-support treatment should stop.
April 11 - Mr Justice Francis says doctors can stop providing life-support treatment after analysing the case at a hearing in the Family Division of the High Court in London.
May 3 - Charlie's parents ask Court of Appeal judges to consider the case.
May 23 - Three Court of Appeal judges analyse the case and dismiss the couple's appeal two days later.
June 8 - Charlie's parents lose fight in the Supreme Court - his mother screams as justices announce their decision.
June 27 - European court judges refuse to intervene.
June 29 - Charlie's parents say his life-support will be switched off on Friday June 30.
July 2 - Pope Francis calls for the couple to be allowed to ''accompany and treat their child until the end'', saying he has followed the case with ''affection and sadness''.
July 3 - US president Donald Trump intervenes, tweeting: ''If we can help little #CharlieGard, as per our friends in the U.K. and the Pope, we would be delighted to do so.''
July 4 - Bambino Gesu, the Vatican's children's hospital in Rome, offers to take Charlie in.
July 10 - Charlie's parents return to the High Court and ask Mr Justice Francis to carry out a fresh analysis of the case. Mr Justice Francis says he will consider any new evidence.
July 17 - Michio Hirano, the New York neurology professor who offered to treat Charlie, travels to London to examine the little boy, discuss the case with Great Ormond Street doctors and other clinicians and examine fresh scans.
July 21 - Lawyer representing Great Ormond Street says a new scan makes for ''sad reading''.
July 24 - Charlie's parents announce their decision to end their legal fight.
July 27 - An order issued by court officials and drawn up by Mr Justice Francis sets out arrangements for Charlie's final hours. The plan will see him move to a hospice, where life-support treatment will be withdrawn soon after.
July 28 - A family spokeswoman confirms Charlie has died.
A court had ordered the 11-month-old to be moved to a hospice from Great Ormond Street Hospital (GOSH) where his life support would be withdrawn.
Charlie's parents Chris Gard and Connie Yates had fought a lengthy legal challenge to take their severely ill baby son to the US for treatment.
The plight of the baby boy saw hundreds of supporters - called Charlie's Army - lending their voices and money for him to be given treatment, with £1.35 million raised on an online fundraising site.