Common meds alter microbiome, increase antibiotic resistance risk

UPI 2 weeks ago

Oct. 23 -- Some widely used drugs alter the population of microbes in the gut, and a number raise the risk of antibiotic resistance, a new Dutch study shows.

The gut microbiome includes at least 1,000 species of bacteria and is influenced by a number of different factors, including medication. Research suggests that changes in the gut microbiome are associated with obesity, diabetes, liver diseases, cancer and neurodegenerative diseases.

"We already know that the efficiency and the toxicity of certain drugs are influenced by the bacterial composition of the gastrointestinal tract and that the gut microbiota has been related to multiple health conditions; therefore, it is crucial to understand which are the consequences of medication use in the gut microbiome," said lead researcher Arnau Vich Vila, from the University Medical Center Groningen.

In this study, the researchers examined 41 commonly used drug categories and assessed 1,883 fecal samples from people who did and didn't take the drugs, including some with irritable bowel syndrome, or IBS, and inflammatory bowel disease, IBD.

Eighteen of the drug categories had major effects on the gut microbiome, and eight increased the risk of antimicrobial resistance.

The categories with the biggest impact on the microbiome were:

  • Proton pump inhibitors, or PPIs, used to treat indigestion, peptic ulcer, H. pylori eradication, gastro reflux and Barrett's esophagus.
  • Metformin, used to treat type 2 diabetes.
  • Antibiotics, used to treat bacterial infections.
  • Laxatives, used to treat and prevent constipation.
The gut microbiomes of PPI users had higher levels of upper gastrointestinal tract bacteria and increased fatty acid production, and metformin users had higher levels of potentially harmful E. coli bacteria.

Seven other drug categories were associated with significant changes in bacterial populations in the gut, according to the researchers.

For example, the use of SSRI antidepressants by people with IBS was associated with increased levels of the potentially harmful bacteria species Eubacterium ramulus.

Meanwhile, the use of oral steroids was associated with high levels of methanogenic bacteria linked with obesity and an increase in body mass index, an estimate of body fat based on weight and height.

The study was to be presented Wednesday at the United European Gastroenterology annual meeting, in Barcelona. Such research is considered preliminary until published in a peer-reviewed journal.

"Our work highlights the importance of considering the role of the gut microbiota when designing treatments and also points to new hypotheses that could explain certain side-effects associated with medication use," Vila said in a meeting news release.

More information

The American Gastroenterological Association has more on the gut microbiome.

Copyright 2019 HealthDay. All rights reserved.


Source link
Read also:
RT › 1 month ago
An ingredient commonly found in green tea could help eliminate antibiotic resistant bacteria - one of the greatest health risks facing our increasingly antibiotic-reliant world. Read Full Article at RT.com
CBS Local › Lifestyle › 1 week ago
Many of our favorite fast food and restaurant chains continue to contribute to the growing threat of antibiotic resistance, according to a report.
Forbes › 3 weeks ago
All too often resistance is seen as a sign that something is wrong. The response is to change direction, to suppress the resistance or just to "power through." I suggest a healthier and more effective response to resistance: Treat it as your friend.
The Guardian › 1 month ago
Research in Florida finds 88% of samples have pathogen that resists at least one antibioticAntibiotic resistance is rising in dolphins, researchers have said, mirroring the trend seen in humans.Scientists examined disease-causing organisms, or...
The New York Times › 1 month ago
Parasitic fungi do not seem to develop resistance to the chemicals, suggesting new ways to prevent antibiotic resistance.
Telegraph › 1 month ago
Antimicrobial resistance (AMR) in chickens and pigs has almost trebled in developing countries since 2000, experts have warned.
The Guardian › Lifestyle › 1 month ago
Global outbreak of antibiotic-resistant superbugs linked to overconsumption of meatHotspots of antibiotic-resistant superbugs are springing up in farms around the world, the direct result of our overconsumption of meat, with potentially disastrous...
The New York Times › Finance › 2 weeks ago
GlaxoSmithKline Plc said on Monday it has begun a late-stage study testing its experimental antibiotic in patients with urinary tract infection and gonorrhoea, a type of sexually transmitted infection.
Daily Mail Online › Lifestyle › 1 week ago
In 2018, there were 61,000 antibiotic resistant infections compared to 56,000 in 2017, a report by Public Health England revealed. Experts said the 'worrying' trend is jeopardising medicine.
The Sun › 1 week ago
THE NHS is warning of a rise in killer superbugs after 61,000 antibiotic resistant infections were reported last year. New figures from Public Health England (PHE) show that there was a nine per cent surge in cases from 2017 to 2018. Brits are now...
Sign In

Sign in to follow sources and tags you love, and get personalized stories.

Continue with Google
OR